Assay Detail
Functional
CHEMBL5584797
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Antiproliferative activity against human A-431 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances in c-Met-based dual inhibitors in the treatment of cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.43 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5598386 | — | — | 1 | 7.00 |
| CHEMBL5590922 | — | — | 1 | 6.16 |
| CHEMBL5597248 | — | — | 1 | 6.12 |
| CHEMBL5596179 | — | — | 1 | - |
| CHEMBL5596051 | — | — | 1 | - |
| CHEMBL5598377 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5598386 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5590922 | — | IC50 | = | 699.4 | nM | 6.16 |
| CHEMBL5597248 | — | IC50 | = | 749.3 | nM | 6.12 |
| CHEMBL5596179 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5596051 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5598377 | — | IC50 | > | 1000.0 | nM | - |