Assay Detail
Binding
CHEMBL5584915
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Inhibition of AChE (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring fluorine-substituted piperidines as potential therapeutics for diabetes mellitus and Alzheimer's diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.14 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.60 |
| CHEMBL5597242 | — | — | 1 | 6.11 |
| CHEMBL5590860 | — | — | 1 | 6.04 |
| CHEMBL5598380 | — | — | 1 | 6.03 |
| CHEMBL5598195 | — | — | 1 | 5.95 |
| CHEMBL5598085 | — | — | 1 | 5.92 |
| CHEMBL5596796 | — | — | 1 | 5.90 |
| CHEMBL5596056 | — | — | 1 | 5.87 |
| CHEMBL5597315 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5597242 | — | IC50 | = | 774.0 | nM | 6.11 |
| CHEMBL5590860 | — | IC50 | = | 916.0 | nM | 6.04 |
| CHEMBL5598380 | — | IC50 | = | 932.0 | nM | 6.03 |
| CHEMBL5598195 | — | IC50 | = | 1119.0 | nM | 5.95 |
| CHEMBL5598085 | — | IC50 | = | 1192.0 | nM | 5.92 |
| CHEMBL5596796 | — | IC50 | = | 1272.0 | nM | 5.90 |
| CHEMBL5596056 | — | IC50 | = | 1362.0 | nM | 5.87 |
| CHEMBL5597315 | — | IC50 | = | 1418.0 | nM | 5.85 |