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Assay Detail

CHEMBL5585017

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MPS1 (unknown origin)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Dual specificity protein kinase TTK (CHEMBL3983)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Hijacking monopolar spindle 1 (MPS1) for various cancer types by small molecular inhibitors: Deep insights from a decade of research and patents.
Liang C, Zhou Y, Xin L, Kang K, Tian L, Zhang D, Li H, Zhao Q, Gao H, Shi Z.
Eur J Med Chem (2024) 273 : 116504 -116504
PubMed 38795520 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 8.34 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5598395 1 9.15
CHEMBL5401292 1 9.14
CHEMBL4449557 1 9.05
CHEMBL4585148 1 9.00
CHEMBL2047959 1 8.70
CHEMBL3092039 1 8.70
CHEMBL3109945 1 8.52
CHEMBL5597789 1 8.34
CHEMBL3092037 1 8.30
CHEMBL5438574 1 8.06
CHEMBL5596286 1 8.06
CHEMBL3092036 1 8.05
CHEMBL3092035 1 7.92
CHEMBL3092030 1 7.70
CHEMBL3092029 1 7.66
CHEMBL7064 1 7.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5598395 IC50 = 0.7 nM 9.15
CHEMBL5401292 IC50 = 0.73 nM 9.14
CHEMBL4449557 IC50 = 0.9 nM 9.05
CHEMBL4585148 IC50 = 1.0 nM 9.00
CHEMBL2047959 IC50 = 2.0 nM 8.70
CHEMBL3092039 IC50 = 2.0 nM 8.70
CHEMBL3109945 IC50 = 3.0 nM 8.52
CHEMBL5597789 IC50 = 4.6 nM 8.34
CHEMBL3092037 IC50 = 5.0 nM 8.30
CHEMBL5438574 IC50 = 8.7 nM 8.06
CHEMBL5596286 IC50 = 8.7 nM 8.06
CHEMBL3092036 IC50 = 9.0 nM 8.05
CHEMBL3092035 IC50 = 12.0 nM 7.92
CHEMBL3092030 IC50 = 20.0 nM 7.70
CHEMBL3092029 IC50 = 22.0 nM 7.66
CHEMBL7064 IC50 = 98.0 nM 7.01