Assay Detail
Binding
CHEMBL5585101
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to METTL3 (unknown origin) assessed as dissociation constant by SPR assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
N6-adenosine-methyltransferase catalytic subunit (CHEMBL4739695) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecules that regulate the N<sup>6</sup>-methyladenosine RNA modification as potential anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 6.60 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 8.32 |
| CHEMBL461101 | ELTROMBOPAG | 4.0 | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | Kd | = | 4.8 | nM | 8.32 |
| CHEMBL461101 | ELTROMBOPAG | Kd | = | 13200.0 | nM | 4.88 |