Assay Detail
Binding
CHEMBL5585102
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ALKBH5 (unknown origin) expressed in Escherichia coli BL21 (DE3) using 5'-ATTGTCA(m6A)CAGCAGA-FAM-3 as substrate pre-incubated for 30 mins followed by substrate addition and measured for 1 hrs by FP based analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small molecules that regulate the N<sup>6</sup>-methyladenosine RNA modification as potential anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.05 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418068 | RHEIN | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418068 | RHEIN | IC50 | = | 9000.0 | nM | 5.05 |