Assay Detail
Binding
CHEMBL5585105
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FTO (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alpha-ketoglutarate-dependent dioxygenase FTO (CHEMBL2331065) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecules that regulate the N<sup>6</sup>-methyladenosine RNA modification as potential anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.85 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5596599 | — | — | 1 | 6.40 |
| CHEMBL1253979 | — | — | 1 | 6.19 |
| CHEMBL5597797 | — | — | 1 | 6.11 |
| CHEMBL5597856 | — | — | 1 | 5.84 |
| CHEMBL418068 | RHEIN | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5596599 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1253979 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5597797 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5597856 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL418068 | RHEIN | IC50 | = | 20000.0 | nM | 4.70 |