Assay Detail
Functional
CHEMBL5585253
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Hep3B cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation, and in silico studies of novel pyridopyridine derivatives as anticancer candidates targeting FMS kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.79 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597533 | — | — | 1 | 6.09 |
| CHEMBL5597674 | — | — | 1 | 6.07 |
| CHEMBL5598003 | — | — | 1 | 5.79 |
| CHEMBL5597526 | — | — | 1 | 5.77 |
| CHEMBL5598552 | — | — | 1 | 5.75 |
| CHEMBL5598141 | — | — | 1 | 5.75 |
| CHEMBL5596963 | — | — | 1 | 5.72 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597533 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL5597674 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5598003 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL5597526 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL5598552 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL5598141 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL5596963 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 4010.0 | nM | 5.40 |