Assay Detail
Binding
CHEMBL5585347
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NanoLuc-fused FMS (unknown origin) transfected in HEK293 cells by NanoBRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, biological evaluation, and in silico studies of novel pyridopyridine derivatives as anticancer candidates targeting FMS kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.41 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1421 | DASATINIB ANHYDROUS | 4.0 | 1 | 7.72 |
| CHEMBL5598003 | — | — | 1 | 6.25 |
| CHEMBL5598552 | — | — | 1 | 5.87 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1421 | DASATINIB ANHYDROUS | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5598003 | — | IC50 | = | 563.0 | nM | 6.25 |
| CHEMBL5598552 | — | IC50 | = | 1347.0 | nM | 5.87 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 1654.0 | nM | 5.78 |