Assay Detail
Functional
CHEMBL5585349
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CSF-1-induced C57BL6 mouse BMDM cell growth preincubated for 1 hr followed by CSF-1 addition and measured after 5 hrs by alamar blue assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BMDM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation, and in silico studies of novel pyridopyridine derivatives as anticancer candidates targeting FMS kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.94 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5598003 | — | — | 1 | 7.25 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 6.79 |
| CHEMBL5598552 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5598003 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL5598552 | — | IC50 | = | 167.0 | nM | 6.78 |