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Target Snapshot

CHEMBL4296525 Target Snapshot

BMDM · CELL-LINE

Back to Search Search this target Browse approvals Evidence Card
555Compounds
290Assays
4Approved Drugs
166.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats BMDM as ChEMBL target CHEMBL4296525. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
BMDM
CELL-LINE
As of 2026-09-14
ChEMBL target ID
CHEMBL4296525
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether BMDM still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBMDM
Target TypeCELL-LINE
OrganismNone
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBMDM
UniProt AccessionN/A

BMDM

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as BMDM.

Review nameBMDM
Clinical Profile

Clinical Phase Distribution

4
Approved
Assay Mix

Activity Type Distribution

IC50166.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4473351 8.7 IC50 2.0 Preclinical
CHEMBL4466924 7.7 IC50 20.0 Preclinical
CHEMBL4847875 7.51 IC50 31.0 Preclinical
CHEMBL4474975 7.4 IC50 40.0 Preclinical
CHEMBL5595602 7.38 IC50 42.0 Preclinical
CHEMBL4588119 7.3 IC50 50.0 Preclinical
CHEMBL3813873 7.25 IC50 56.0 Approved
CHEMBL5598003 7.25 IC50 56.0 Preclinical
CHEMBL4535055 7.22 IC50 60.0 Preclinical
CHEMBL510698 7.17 IC50 67.0 Preclinical
Distribution

pChEMBL Value Distribution

33
5.0
38
5.5
12
6.0
15
6.5
8
7.0
2
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PEXIDARTINIB
CHEMBL3813873
Approved 2019
Properties Compare Identifier
SORAFENIB
CHEMBL1336
Approved 2005
Properties Compare Identifier
ALENDRONATE SODIUM
CHEMBL675
Approved 1995
Properties Compare Identifier
Assay Landscape

Assay Landscape

290
Total Assays
109
Tested Compounds
3
Assay Types
Functional — 244 assays, 109 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 244 109 5.9
Toxicity — 25 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 25 2 —
ADME — 21 assays, 7 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 21 7 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine