Compound Detail
CHEMBL4847875
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Basic Information
| ChEMBL ID | CHEMBL4847875 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ORYMWWSJZRCUSV-UHFFFAOYSA-N |
10
Targets
13
Activities
2
Assay Types
5
PK Parameters
16
Publications
0
Known Names
Molecular Properties
482.5
MW (Da)
5.22
ALogP
6
HBA
2
HBD
92.3
PSA (Ų)
0.39
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 11 meas. best 9.28
EC50 2 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 9.28 | 8.56 | 0.5 | 2 |
| Mast/stem cell growth factor receptor Kit CHEMBL1936 | IC50 | 8.96 | 8.96 | 1.1 | 1 |
| BMDM CHEMBL4296525 | IC50 | 7.51 | 6.39 | 31.0 | 2 |
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 7.5 | 7.5 | 31.5 | 1 |
| Platelet-derived growth factor receptor alpha CHEMBL2007 | IC50 | 7.28 | 7.28 | 52.7 | 1 |
| Epithelial discoidin domain-containing receptor 1 CHEMBL5319 | IC50 | 7.22 | 7.22 | 59.7 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 7.19 | 7.19 | 64.3 | 1 |
| BaF3 CHEMBL614524 | EC50 | 7.1 | 7.1 | 80.0 | 1 |
| NFS-60 CHEMBL614199 | EC50 | 7.02 | 7.02 | 95.0 | 1 |
| Aurora kinase B CHEMBL2185 | IC50 | 6.65 | 6.25 | 226.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 4.5 | mL.min-1.kg-1 | Rattus norvegicus |
| F | 10.0 | % | Rattus norvegicus |
| T1/2 | 2.9 | hr | Rattus norvegicus |
| T1/2 | 8.7 | hr | Rattus norvegicus |
| Tmax | 5.5 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine