Assay Detail
Functional
CHEMBL4845014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse NFS-60 cells transfected with human ETV6-CSF1R assessed as reduction in cell viability measured after 72 hrs by MTS method
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NFS-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 7.03 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4846051 | — | — | 1 | 7.64 |
| CHEMBL4877440 | — | — | 1 | 7.64 |
| CHEMBL4846414 | — | — | 1 | 7.60 |
| CHEMBL4877148 | — | — | 1 | 7.28 |
| CHEMBL4860468 | — | — | 1 | 7.26 |
| CHEMBL4873828 | — | — | 1 | 7.24 |
| CHEMBL4870360 | — | — | 1 | 7.17 |
| CHEMBL4846384 | — | — | 1 | 7.17 |
| CHEMBL4851635 | — | — | 1 | 7.16 |
| CHEMBL1908396 | — | — | 1 | 7.11 |
| CHEMBL4870448 | — | — | 1 | 7.09 |
| CHEMBL4877247 | — | — | 1 | 7.04 |
| CHEMBL4847875 | — | — | 1 | 7.02 |
| CHEMBL4854210 | — | — | 1 | 7.01 |
| CHEMBL4857271 | — | — | 1 | 6.97 |
| CHEMBL4859405 | — | — | 1 | 6.85 |
| CHEMBL4857617 | — | — | 1 | 6.84 |
| CHEMBL4864248 | — | — | 1 | 6.84 |
| CHEMBL4878471 | — | — | 1 | 6.82 |
| CHEMBL4849425 | — | — | 1 | 6.79 |
| CHEMBL4863584 | — | — | 1 | 6.70 |
| CHEMBL3813873 | PEXIDARTINIB | 4.0 | 1 | 6.53 |
| CHEMBL4857690 | — | — | 1 | 5.96 |
| CHEMBL4866196 | — | — | 1 | - |
| CHEMBL4878293 | — | — | 1 | - |
| CHEMBL4851545 | — | — | 1 | - |
| CHEMBL4876396 | — | — | 1 | - |
| CHEMBL4878431 | — | — | 1 | - |
| CHEMBL4874053 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4846051 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4877440 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4846414 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4877148 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4860468 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4873828 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4870360 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4846384 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4851635 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1908396 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4870448 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4877247 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4847875 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4854210 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4857271 | — | EC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4859405 | — | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL4857617 | — | EC50 | = | 144.0 | nM | 6.84 |
| CHEMBL4864248 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4878471 | — | EC50 | = | 152.0 | nM | 6.82 |
| CHEMBL4849425 | — | EC50 | = | 162.0 | nM | 6.79 |
| CHEMBL4863584 | — | EC50 | = | 202.0 | nM | 6.70 |
| CHEMBL3813873 | PEXIDARTINIB | EC50 | = | 294.0 | nM | 6.53 |
| CHEMBL4857690 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4866196 | — | EC50 | - | — | - | |
| CHEMBL4878293 | — | EC50 | - | — | - | |
| CHEMBL4851545 | — | EC50 | - | — | - | |
| CHEMBL4876396 | — | EC50 | - | — | - | |
| CHEMBL4878431 | — | EC50 | - | — | - | |
| CHEMBL4874053 | — | EC50 | - | — | - |