Compound Detail
CHEMBL4846051
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Basic Information
| ChEMBL ID | CHEMBL4846051 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QHVBLGCKKMQNAF-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
438.5
MW (Da)
4.68
ALogP
6
HBA
2
HBD
103.2
PSA (Ų)
0.45
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.85
IC50 1 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| BaF3 CHEMBL614524 | EC50 | 7.85 | 7.85 | 14.1 | 1 |
| NFS-60 CHEMBL614199 | EC50 | 7.64 | 7.64 | 23.0 | 1 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 7.3 | 7.3 | 50.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| BaF3 | EC50 | = | 14.1 | nM | 7.85 | Antiproliferative activity against mouse BaF3 cells transfected with human ETV6-... | 34606263 |
| NFS-60 | EC50 | = | 23.0 | nM | 7.64 | Antiproliferative activity against mouse NFS-60 cells transfected with human ETV... | 34606263 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 50.0 | nM | 7.3 | Inhibition of human recombinant GST-CSF1R (residues L534 to C972) expressed in S... | 34606263 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34606263 | 10.1021/acs.jmedchem.1c01006 | Macrophage colony-stimulating factor 1 receptor | 1 |
| 34606263 | 10.1021/acs.jmedchem.1c01006 | Aurora kinase A | 1 |
| 34606263 | 10.1021/acs.jmedchem.1c01006 | Aurora kinase B | 1 |
| 34606263 | 10.1021/acs.jmedchem.1c01006 | BaF3 | 1 |
| 34606263 | 10.1021/acs.jmedchem.1c01006 | NFS-60 | 1 |
Data from ChEMBL 36 via Core Engine