Assay Detail
Binding
CHEMBL4845012
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant full length GST-AURKB using tetra(-LRRASLG) peptide as substrate incubated for 20 mins by ATP Kinase Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.90 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4864729 | — | — | 1 | 7.89 |
| CHEMBL4877440 | — | — | 1 | 7.65 |
| CHEMBL3813873 | PEXIDARTINIB | 4.0 | 1 | 6.19 |
| CHEMBL4847875 | — | — | 1 | 5.85 |
| CHEMBL4877247 | — | — | 1 | - |
| CHEMBL4851635 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4864729 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4877440 | — | IC50 | = | 22.2 | nM | 7.65 |
| CHEMBL3813873 | PEXIDARTINIB | IC50 | = | 643.0 | nM | 6.19 |
| CHEMBL4847875 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4877247 | — | IC50 | - | — | - | |
| CHEMBL4851635 | — | IC50 | - | — | - |