Assay Detail
Functional
CHEMBL5585459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against recombinant Ebola virus Mayinga expressing GFP infected in human HeLa cells with ATP6V0a2 KO assessed as reduction in viral entry into cells pretreated for 1 hr followed by viral infection measured after 24 to 48 hrs by imaging analysis
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Ebolavirus |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evaluation of potency and metabolic stability of diphyllin-derived Vacuolar-ATPase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 35 | 7.20 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290814 | BAFILOMYCIN A1 | — | 1 | 8.52 |
| CHEMBL5596649 | — | — | 1 | 8.15 |
| CHEMBL5591196 | — | — | 1 | 8.15 |
| CHEMBL5596191 | — | — | 1 | 8.00 |
| CHEMBL5597241 | — | — | 1 | 7.75 |
| CHEMBL5598489 | — | — | 1 | 7.66 |
| CHEMBL5596937 | — | — | 1 | 7.58 |
| CHEMBL5596240 | — | — | 1 | 7.55 |
| CHEMBL5598420 | — | — | 1 | 7.51 |
| CHEMBL5590402 | — | — | 1 | 7.50 |
| CHEMBL5598132 | — | — | 1 | 7.46 |
| CHEMBL5590448 | — | — | 1 | 7.44 |
| CHEMBL5590879 | — | — | 1 | 7.43 |
| CHEMBL5596788 | — | — | 1 | 7.40 |
| CHEMBL5598387 | — | — | 1 | 7.39 |
| CHEMBL5596144 | — | — | 1 | 7.38 |
| CHEMBL5597447 | — | — | 1 | 7.36 |
| CHEMBL5596254 | — | — | 1 | 7.32 |
| CHEMBL5597831 | — | — | 1 | 7.27 |
| CHEMBL5597227 | — | — | 1 | 7.13 |
| CHEMBL5598529 | — | — | 1 | 7.07 |
| CHEMBL5596568 | — | — | 1 | 7.02 |
| CHEMBL5597921 | — | — | 1 | 6.94 |
| CHEMBL5596938 | — | — | 1 | 6.93 |
| CHEMBL5596482 | — | — | 1 | 6.91 |
| CHEMBL5596264 | — | — | 1 | 6.90 |
| CHEMBL5597205 | — | — | 1 | 6.84 |
| CHEMBL5597937 | — | — | 1 | 6.80 |
| CHEMBL5596535 | — | — | 1 | 6.74 |
| CHEMBL5597260 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290814 | BAFILOMYCIN A1 | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5596649 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5591196 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5596191 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5597241 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5598489 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5596937 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5596240 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5598420 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5590402 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5598132 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5590448 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5590879 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5596788 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5598387 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5596144 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5597447 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5596254 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5597831 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5597227 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5598529 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5596568 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL5597921 | — | EC50 | = | 116.0 | nM | 6.94 |
| CHEMBL5596938 | — | EC50 | = | 117.0 | nM | 6.93 |
| CHEMBL5596482 | — | EC50 | = | 124.0 | nM | 6.91 |
| CHEMBL5596264 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL5597205 | — | EC50 | = | 143.0 | nM | 6.84 |
| CHEMBL5597937 | — | EC50 | = | 157.0 | nM | 6.80 |
| CHEMBL5596535 | — | EC50 | = | 182.0 | nM | 6.74 |
| CHEMBL5597260 | — | EC50 | = | 214.0 | nM | 6.67 |
| CHEMBL5590637 | — | EC50 | = | 318.0 | nM | 6.50 |
| CHEMBL458904 | PATENTIFLORIN A | EC50 | = | 428.0 | nM | 6.37 |
| CHEMBL5598341 | — | EC50 | = | 441.0 | nM | 6.36 |
| CHEMBL5596273 | — | EC50 | = | 651.0 | nM | 6.19 |
| CHEMBL221190 | DIPHYLLIN | EC50 | = | 1086.0 | nM | 5.96 |