Assay Detail
Binding
CHEMBL5585480
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Inhibition of human salivary alpha-amylase incubated for 10 mins by spectrophotometric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of new anti-diabetic potential agents based on paracetamol incorporating sulfa-drugs: Design, synthesis, α-amylase, and α-glucosidase inhibitors with molecular docking simulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.43 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | 6.37 |
| CHEMBL5597515 | — | — | 1 | 6.01 |
| CHEMBL5597113 | — | — | 1 | 5.81 |
| CHEMBL5597693 | — | — | 1 | 5.80 |
| CHEMBL5596134 | — | — | 1 | 5.23 |
| CHEMBL5596871 | — | — | 1 | 5.08 |
| CHEMBL5596261 | — | — | 1 | 5.08 |
| CHEMBL5596823 | — | — | 1 | 4.86 |
| CHEMBL5596319 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404271 | ACARBOSE | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5597515 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5597113 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL5597693 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL5596134 | — | IC50 | = | 5940.0 | nM | 5.23 |
| CHEMBL5596871 | — | IC50 | = | 8350.0 | nM | 5.08 |
| CHEMBL5596261 | — | IC50 | = | 8370.0 | nM | 5.08 |
| CHEMBL5596823 | — | IC50 | = | 13790.0 | nM | 4.86 |
| CHEMBL5596319 | — | IC50 | = | 22660.0 | nM | 4.64 |