Assay Detail
Binding
CHEMBL5585679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel dihydropyrimidines as promising EGFR & HER2 inhibitors: Insights from experimental and computational studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.99 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 8.32 |
| CHEMBL2110732 | DACOMITINIB ANHYDROUS | 4.0 | 1 | 8.22 |
| CHEMBL3786343 | OLMUTINIB | 4.0 | 1 | 8.04 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 7.97 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.89 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL2110732 | DACOMITINIB ANHYDROUS | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3786343 | OLMUTINIB | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL554 | LAPATINIB | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 12.92 | nM | 7.89 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 30.0 | nM | 7.52 |