Assay Detail
Binding
CHEMBL5585744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor extracted from HEK293 cell membrane by microbeta plate reader analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-HT<sub>6</sub> receptor neutral antagonists protect astrocytes: A lesson from 2-phenylpyrrole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.34 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5596350 | — | — | 1 | 6.12 |
| CHEMBL5597256 | — | — | 1 | 6.04 |
| CHEMBL5598162 | — | — | 1 | 5.74 |
| CHEMBL5597699 | — | — | 1 | 5.61 |
| CHEMBL5597355 | — | — | 1 | 4.39 |
| CHEMBL5598097 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5596350 | — | Ki | = | 755.0 | nM | 6.12 |
| CHEMBL5597256 | — | Ki | = | 916.0 | nM | 6.04 |
| CHEMBL5598162 | — | Ki | = | 1839.0 | nM | 5.74 |
| CHEMBL5597699 | — | Ki | = | 2473.0 | nM | 5.61 |
| CHEMBL5597355 | — | Ki | = | 40610.0 | nM | 4.39 |
| CHEMBL5598097 | — | Ki | = | 68610.0 | nM | 4.16 |