Assay Detail
Functional
CHEMBL5585778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 T125A infected in human MT4 cells assessed as reduction in viral replication
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.16 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.41 |
| CHEMBL5597897 | — | — | 1 | 6.92 |
| CHEMBL5597609 | — | — | 1 | 6.89 |
| CHEMBL5597978 | — | — | 1 | 6.24 |
| CHEMBL5596288 | — | — | 1 | 6.03 |
| CHEMBL5597870 | — | — | 1 | 5.92 |
| CHEMBL5596946 | — | — | 1 | 5.57 |
| CHEMBL5596381 | — | — | 1 | 5.48 |
| CHEMBL5597523 | — | — | 1 | 5.00 |
| CHEMBL5596283 | — | — | 1 | - |
| CHEMBL5598287 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 38.9 | nM | 7.41 |
| CHEMBL5597897 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5597609 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5597978 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5596288 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5597870 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5596946 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5596381 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5597523 | — | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL5596283 | — | EC50 | > | 6000.0 | nM | - |
| CHEMBL5598287 | — | EC50 | > | 6000.0 | nM | - |