Assay Detail
Binding
CHEMBL5585900
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PD-1/PD-L1 interaction in human Jurkat T cells co-cultured with CHO/TCRAct/PDL1 cells assessed as restoration of T cell activation measured for 6 hrs by luminescence based immune checkpoint blockade assay
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
N-methylmorpholine incorporation into the structure of biphenyl leads to the bioactive inhibitor of PD-1/PD-L1 interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.85 | 7.77 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5398278 | — | — | 1 | 7.77 |
| CHEMBL5078455 | — | — | 1 | 5.18 |
| CHEMBL5597858 | — | — | 2 | 4.59 |
| CHEMBL5597887 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5398278 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5078455 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL5597858 | — | EC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL5597858 | — | Inhibition | - | % | - | |
| CHEMBL5597887 | — | Inhibition | - | % | - |