Assay Detail
Binding
CHEMBL5585905
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PD-1/PD-L1 interaction incubated for 1 hr by HTRF assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
N-methylmorpholine incorporation into the structure of biphenyl leads to the bioactive inhibitor of PD-1/PD-L1 interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.82 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5398278 | — | — | 1 | 9.40 |
| CHEMBL5597858 | — | — | 1 | 7.11 |
| CHEMBL5597887 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5398278 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5597858 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL5597887 | — | IC50 | = | 109.0 | nM | 6.96 |