Assay Detail
Toxicity
CHEMBL5586213
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Chlorocebus sabaeus |
| Cell Type | Vero |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel flexible biphenyl <i>Pf</i>DHFR inhibitors with improved antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.12 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5598010 | — | — | 1 | 6.24 |
| CHEMBL5597998 | — | — | 1 | 5.18 |
| CHEMBL5597280 | — | — | 1 | 4.85 |
| CHEMBL5597152 | — | — | 1 | 4.84 |
| CHEMBL5598041 | — | — | 1 | 4.47 |
| CHEMBL5596188 | — | — | 1 | - |
| CHEMBL5597854 | — | — | 1 | - |
| CHEMBL5590041 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5598010 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5597998 | — | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL5597280 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL5597152 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL5598041 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL5596188 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5597854 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5590041 | — | IC50 | > | 50000.0 | nM | - |