Assay Detail
Binding
CHEMBL5586702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IP6K1 (unknown origin) using IP6 as substrate incubated for 30 mins in presence of ATP by ADPGlo enzymatic assay
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inositol hexakisphosphate kinase 1 (CHEMBL4523418) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and Characterization of a Blood-Brain Barrier Penetrant Inositol Hexakisphosphate Kinase (IP6K) Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 68 | 6.81 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5598155 | — | — | 1 | 8.77 |
| CHEMBL5598038 | — | — | 1 | 8.60 |
| CHEMBL5190343 | — | — | 1 | 8.54 |
| CHEMBL5596194 | — | — | 1 | 8.49 |
| CHEMBL5590726 | — | — | 1 | 8.44 |
| CHEMBL5598068 | — | — | 1 | 8.19 |
| CHEMBL5598514 | — | — | 1 | 8.16 |
| CHEMBL5597913 | — | — | 1 | 8.10 |
| CHEMBL5596094 | — | — | 1 | 8.10 |
| CHEMBL5598435 | — | — | 1 | 8.03 |
| CHEMBL5597090 | — | — | 1 | 7.80 |
| CHEMBL5590042 | — | — | 1 | 7.80 |
| CHEMBL5598271 | — | — | 1 | 7.57 |
| CHEMBL5596469 | — | — | 1 | 7.55 |
| CHEMBL5597088 | — | — | 1 | 7.55 |
| CHEMBL5596929 | — | — | 1 | 7.52 |
| CHEMBL5597637 | — | — | 1 | 7.51 |
| CHEMBL5596184 | — | — | 1 | 7.46 |
| CHEMBL5596237 | — | — | 1 | 7.44 |
| CHEMBL5596303 | — | — | 1 | 7.41 |
| CHEMBL5597391 | — | — | 1 | 7.37 |
| CHEMBL5598451 | — | — | 1 | 7.18 |
| CHEMBL5596764 | — | — | 1 | 7.17 |
| CHEMBL5596099 | — | — | 1 | 7.11 |
| CHEMBL5596496 | — | — | 1 | 7.11 |
| CHEMBL5596638 | — | — | 1 | 7.08 |
| CHEMBL5598241 | — | — | 1 | 7.05 |
| CHEMBL5597127 | — | — | 1 | 6.96 |
| CHEMBL5597596 | — | — | 1 | 6.89 |
| CHEMBL5596161 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5598155 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5598038 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5190343 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5596194 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5590726 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5598068 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL5598514 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5597913 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5596094 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5598435 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL5597090 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5590042 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5598271 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5597088 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5596469 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5596929 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5597637 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5596184 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5596237 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5596303 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5597391 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5598451 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5596764 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL5596099 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL5596496 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5596638 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL5598241 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5597127 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5597596 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5596161 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5596437 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5597163 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5596409 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5596215 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5597747 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5598518 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5597372 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5597385 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5597655 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5597126 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5597196 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5597108 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5596117 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5597161 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5596265 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5597780 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5597428 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5597232 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5598366 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5597177 | — | IC50 | = | 790.0 | nM | 6.10 |