Assay Detail
Binding
CHEMBL5586782
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Inhibition of URAT1 (unknown origin) by absorbance based assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Orally Bioavailable Xanthine Oxidase/Urate Transporter 1 Dual Inhibitor as a Potential Treatment for Hyperuricemia and Gout.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.36 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5591047 | — | — | 1 | 7.51 |
| CHEMBL5597034 | — | — | 1 | 7.43 |
| CHEMBL5598112 | — | — | 1 | 7.35 |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 1 | 7.32 |
| CHEMBL5597097 | — | — | 1 | 6.98 |
| CHEMBL5596181 | — | — | 1 | 6.97 |
| CHEMBL5598394 | — | — | 1 | 6.85 |
| CHEMBL5597164 | — | — | 1 | 6.76 |
| CHEMBL5597960 | — | — | 1 | 6.45 |
| CHEMBL5598423 | — | — | 1 | 6.35 |
| CHEMBL5597556 | — | — | 1 | 6.22 |
| CHEMBL5596244 | — | — | 1 | 6.21 |
| CHEMBL5598004 | — | — | 1 | 5.78 |
| CHEMBL5596444 | — | — | 1 | 5.66 |
| CHEMBL5598490 | — | — | 1 | 5.54 |
| CHEMBL5590136 | — | — | 1 | 5.50 |
| CHEMBL5590746 | — | — | 1 | 5.44 |
| CHEMBL5596964 | — | — | 1 | 5.43 |
| CHEMBL5590748 | — | — | 1 | 5.08 |
| CHEMBL5597135 | — | — | 1 | - |
| CHEMBL5598240 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5591047 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5597034 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5598112 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5597097 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL5596181 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL5598394 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5597164 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL5597960 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL5598423 | — | IC50 | = | 444.0 | nM | 6.35 |
| CHEMBL5597556 | — | IC50 | = | 598.0 | nM | 6.22 |
| CHEMBL5596244 | — | IC50 | = | 623.0 | nM | 6.21 |
| CHEMBL5598004 | — | IC50 | = | 1652.0 | nM | 5.78 |
| CHEMBL5596444 | — | IC50 | = | 2196.0 | nM | 5.66 |
| CHEMBL5598490 | — | IC50 | = | 2875.0 | nM | 5.54 |
| CHEMBL5590136 | — | IC50 | = | 3189.0 | nM | 5.50 |
| CHEMBL5590746 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL5596964 | — | IC50 | = | 3747.0 | nM | 5.43 |
| CHEMBL5590748 | — | IC50 | = | 8302.0 | nM | 5.08 |
| CHEMBL5597135 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5598240 | — | IC50 | > | 10000.0 | nM | - |