Assay Detail
Functional
CHEMBL5586930
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HL-60 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Mcl-1 Inhibitors with a 3-Substituted-1<i>H</i>-indole-1-yl Moiety Binding to the P1-P3 Pockets to Induce Apoptosis in Acute Myeloid Leukemia Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 4.74 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5596340 | — | — | 1 | 5.28 |
| CHEMBL3417704 | — | — | 1 | 5.26 |
| CHEMBL5598470 | — | — | 1 | 5.12 |
| CHEMBL5597184 | — | — | 1 | 5.10 |
| CHEMBL5598253 | — | — | 1 | 5.10 |
| CHEMBL5596228 | — | — | 1 | 5.05 |
| CHEMBL5597895 | — | — | 1 | 5.05 |
| CHEMBL5598100 | — | — | 1 | 4.99 |
| CHEMBL5596331 | — | — | 1 | 4.98 |
| CHEMBL5597331 | — | — | 1 | 4.91 |
| CHEMBL5598101 | — | — | 1 | 4.90 |
| CHEMBL5598402 | — | — | 1 | 4.89 |
| CHEMBL5597821 | — | — | 1 | 4.85 |
| CHEMBL5597453 | — | — | 1 | 4.85 |
| CHEMBL5591262 | — | — | 1 | 4.84 |
| CHEMBL5596655 | — | — | 1 | 4.82 |
| CHEMBL5596761 | — | — | 1 | 4.80 |
| CHEMBL5598466 | — | — | 1 | 4.79 |
| CHEMBL5597362 | — | — | 1 | 4.77 |
| CHEMBL5596118 | — | — | 1 | 4.74 |
| CHEMBL5596126 | — | — | 1 | 4.71 |
| CHEMBL5597099 | — | — | 1 | 4.67 |
| CHEMBL5598447 | — | — | 1 | 4.67 |
| CHEMBL5596249 | — | — | 1 | 4.55 |
| CHEMBL5596754 | — | — | 1 | 4.55 |
| CHEMBL5597752 | — | — | 1 | 4.55 |
| CHEMBL5596515 | — | — | 1 | 4.54 |
| CHEMBL5589824 | — | — | 1 | 4.52 |
| CHEMBL5596355 | — | — | 1 | 4.52 |
| CHEMBL5598198 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5596340 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3417704 | — | IC50 | = | 5530.0 | nM | 5.26 |
| CHEMBL5598470 | — | IC50 | = | 7580.0 | nM | 5.12 |
| CHEMBL5597184 | — | IC50 | = | 7920.0 | nM | 5.10 |
| CHEMBL5598253 | — | IC50 | = | 7960.0 | nM | 5.10 |
| CHEMBL5596228 | — | IC50 | = | 8910.0 | nM | 5.05 |
| CHEMBL5597895 | — | IC50 | = | 8820.0 | nM | 5.05 |
| CHEMBL5598100 | — | IC50 | = | 10140.0 | nM | 4.99 |
| CHEMBL5596331 | — | IC50 | = | 10480.0 | nM | 4.98 |
| CHEMBL5597331 | — | IC50 | = | 12280.0 | nM | 4.91 |
| CHEMBL5598101 | — | IC50 | = | 12590.0 | nM | 4.90 |
| CHEMBL5598402 | — | IC50 | = | 12820.0 | nM | 4.89 |
| CHEMBL5597821 | — | IC50 | = | 14120.0 | nM | 4.85 |
| CHEMBL5597453 | — | IC50 | = | 14210.0 | nM | 4.85 |
| CHEMBL5591262 | — | IC50 | = | 14280.0 | nM | 4.84 |
| CHEMBL5596655 | — | IC50 | = | 15130.0 | nM | 4.82 |
| CHEMBL5596761 | — | IC50 | = | 15650.0 | nM | 4.80 |
| CHEMBL5598466 | — | IC50 | = | 16090.0 | nM | 4.79 |
| CHEMBL5597362 | — | IC50 | = | 16810.0 | nM | 4.77 |
| CHEMBL5596118 | — | IC50 | = | 18280.0 | nM | 4.74 |
| CHEMBL5596126 | — | IC50 | = | 19270.0 | nM | 4.71 |
| CHEMBL5598447 | — | IC50 | = | 21120.0 | nM | 4.67 |
| CHEMBL5597099 | — | IC50 | = | 21220.0 | nM | 4.67 |
| CHEMBL5596249 | — | IC50 | = | 28450.0 | nM | 4.55 |
| CHEMBL5596754 | — | IC50 | = | 28040.0 | nM | 4.55 |
| CHEMBL5597752 | — | IC50 | = | 28290.0 | nM | 4.55 |
| CHEMBL5596515 | — | IC50 | = | 28840.0 | nM | 4.54 |
| CHEMBL5589824 | — | IC50 | = | 29930.0 | nM | 4.52 |
| CHEMBL5596355 | — | IC50 | = | 30480.0 | nM | 4.52 |
| CHEMBL5598198 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL5597387 | — | IC50 | = | 31550.0 | nM | 4.50 |
| CHEMBL5597484 | — | IC50 | = | 31910.0 | nM | 4.50 |
| CHEMBL5598278 | — | IC50 | = | 32210.0 | nM | 4.49 |
| CHEMBL5598182 | — | IC50 | = | 35040.0 | nM | 4.46 |
| CHEMBL5597673 | — | IC50 | = | 34870.0 | nM | 4.46 |
| CHEMBL5598497 | — | IC50 | = | 35070.0 | nM | 4.46 |
| CHEMBL5596613 | — | IC50 | = | 39120.0 | nM | 4.41 |
| CHEMBL5596354 | — | IC50 | = | 44060.0 | nM | 4.36 |
| CHEMBL5598418 | — | IC50 | = | 47750.0 | nM | 4.32 |
| CHEMBL5597585 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5596206 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2314193 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5597551 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5598173 | — | IC50 | > | 50000.0 | nM | - |