Assay Detail
Functional
CHEMBL5587080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human U-87 MG cells incubated for 48 hrs by CCK8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid Derivatives as PP5 Inhibitors To Reverse Temozolomide Resistance in Glioblastoma Multiforme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.37 | 4.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597987 | — | — | 1 | 4.59 |
| CHEMBL5597580 | — | — | 1 | 4.15 |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597987 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL5597580 | — | IC50 | = | 70100.0 | nM | 4.15 |
| CHEMBL810 | TEMOZOLOMIDE | IC50 | > | 200000.0 | nM | - |