Assay Detail
Binding
CHEMBL5587316
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type TRKA (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Solvent-Front Mutations for Kinase Drug Discovery: From Structural Basis to Design Strategies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.85 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5075273 | — | — | 1 | 9.40 |
| CHEMBL5078405 | — | — | 1 | 9.30 |
| CHEMBL5092943 | — | — | 1 | 7.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5075273 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5078405 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5092943 | — | IC50 | = | 14.3 | nM | 7.84 |