Assay Detail
Binding
CHEMBL5587334
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Inhibition of EGFR Del19/T790M/C797S mutant (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting Solvent-Front Mutations for Kinase Drug Discovery: From Structural Basis to Design Strategies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.88 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597724 | — | — | 1 | 9.70 |
| CHEMBL4443062 | — | — | 1 | 9.70 |
| CHEMBL5591124 | — | — | 1 | 8.51 |
| CHEMBL4284413 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597724 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4443062 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5591124 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4284413 | — | IC50 | = | 24.0 | nM | 7.62 |