Assay Detail
Binding
CHEMBL5587482
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Inhibition of SARS CoV-2 MPro
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Nonpeptidic Irreversible Inhibitors of SARS-CoV-2 Main Protease with Potent Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.50 | 8.44 |
| Ki | 2 | 7.80 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 2 | 8.51 |
| CHEMBL5205750 | — | — | 1 | 7.47 |
| CHEMBL468553 | — | — | 1 | 7.09 |
| CHEMBL490820 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4802135 | NIRMATRELVIR | Ki | = | 3.11 | nM | 8.51 |
| CHEMBL4802135 | NIRMATRELVIR | IC50 | = | 3.62 | nM | 8.44 |
| CHEMBL5205750 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL468553 | — | Ki | = | 81.12 | nM | 7.09 |
| CHEMBL490820 | — | IC50 | = | 250.0 | nM | 6.60 |