Assay Detail
Binding
CHEMBL5587982
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Binding affinity to human recombinant CA II assessed as dissociation constant
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigating Active Site Binding of Ligands to High and Low Activity Carbonic Anhydrase Enzymes Using Native Mass Spectrometry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 5.96 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406 | INDAPAMIDE | 4.0 | 1 | 6.89 |
| CHEMBL35 | FUROSEMIDE | 4.0 | 1 | 6.20 |
| CHEMBL1684 | BENDROFLUMETHIAZIDE | 4.0 | 1 | 5.77 |
| CHEMBL1054 | TRICHLORMETHIAZIDE | 4.0 | 1 | 5.77 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | 4.0 | 1 | 5.58 |
| CHEMBL878 | METOLAZONE | 4.0 | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406 | INDAPAMIDE | Kd | = | 130.0 | nM | 6.89 |
| CHEMBL35 | FUROSEMIDE | Kd | = | 630.0 | nM | 6.20 |
| CHEMBL1684 | BENDROFLUMETHIAZIDE | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL1054 | TRICHLORMETHIAZIDE | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Kd | = | 2600.0 | nM | 5.58 |
| CHEMBL878 | METOLAZONE | Kd | = | 2800.0 | nM | 5.55 |