Assay Detail
Binding
CHEMBL5588007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 2 hrs by Western blot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL2189158) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of Pyrazolo[1,5-<i>a</i>]pyridine Derivatives as Potent and Selective PI3Kγ/δ Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.35 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597218 | — | — | 1 | 7.55 |
| CHEMBL3039502 | DUVELISIB | 4.0 | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597218 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3039502 | DUVELISIB | EC50 | = | 72.0 | nM | 7.14 |