Assay Detail
Functional
CHEMBL5588079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT-116 cells harboring KRAS G13D mutant incubated for 72 hrs by CCK8 assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 5-Amino-4-fluoro-1<i>H</i>-benzo[<i>d</i>]imidazole-6-carboxamide Derivatives as Novel and Potential MEK/RAF Complex Inhibitors Based on the "Clamp" Strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.55 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5596553 | — | — | 1 | 7.13 |
| CHEMBL5597316 | — | — | 1 | 7.10 |
| CHEMBL5597470 | — | — | 1 | 6.95 |
| CHEMBL5596257 | — | — | 1 | 6.91 |
| CHEMBL5598180 | — | — | 1 | 6.88 |
| CHEMBL5596481 | — | — | 1 | 6.85 |
| CHEMBL5596979 | — | — | 1 | 6.82 |
| CHEMBL5596447 | — | — | 1 | 6.76 |
| CHEMBL5597799 | — | — | 1 | 6.74 |
| CHEMBL5596544 | — | — | 1 | 6.70 |
| CHEMBL5597586 | — | — | 1 | 6.65 |
| CHEMBL5596121 | — | — | 1 | 6.45 |
| CHEMBL5598512 | — | — | 1 | 6.42 |
| CHEMBL5597923 | — | — | 1 | 6.37 |
| CHEMBL5597539 | — | — | 1 | 6.34 |
| CHEMBL5597513 | — | — | 1 | 6.20 |
| CHEMBL5598207 | — | — | 1 | 6.16 |
| CHEMBL5598292 | — | — | 1 | 6.14 |
| CHEMBL3264002 | AVUTOMETINIB | 3.0 | 1 | 6.13 |
| CHEMBL5598214 | — | — | 1 | 6.05 |
| CHEMBL3187723 | BINIMETINIB | 4.0 | 1 | 5.70 |
| CHEMBL5597535 | — | — | 1 | - |
| CHEMBL5598115 | — | — | 1 | - |
| CHEMBL5596397 | — | — | 1 | - |
| CHEMBL5596352 | — | — | 1 | - |
| CHEMBL5597532 | — | — | 1 | - |
| CHEMBL5591121 | — | — | 1 | - |
| CHEMBL5597425 | — | — | 1 | - |
| CHEMBL5597695 | — | — | 1 | - |
| CHEMBL5598254 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5596553 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5597316 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5597470 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL5596257 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL5598180 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL5596481 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5596979 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5596447 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL5597799 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL5596544 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL5597586 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL5596121 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL5598512 | — | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL5597923 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL5597539 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL5597513 | — | IC50 | = | 626.0 | nM | 6.20 |
| CHEMBL5598207 | — | IC50 | = | 694.0 | nM | 6.16 |
| CHEMBL5598292 | — | IC50 | = | 731.0 | nM | 6.14 |
| CHEMBL3264002 | AVUTOMETINIB | IC50 | = | 739.0 | nM | 6.13 |
| CHEMBL5598214 | — | IC50 | = | 898.0 | nM | 6.05 |
| CHEMBL3187723 | BINIMETINIB | IC50 | = | 1997.0 | nM | 5.70 |
| CHEMBL5590964 | — | IC50 | - | — | - | |
| CHEMBL5597616 | — | IC50 | - | — | - | |
| CHEMBL5596617 | — | IC50 | - | — | - | |
| CHEMBL5596318 | — | IC50 | - | — | - | |
| CHEMBL5597679 | — | IC50 | - | — | - | |
| CHEMBL5598403 | — | IC50 | - | — | - | |
| CHEMBL5597745 | — | IC50 | - | — | - | |
| CHEMBL5596682 | — | IC50 | - | — | - | |
| CHEMBL5597128 | — | IC50 | - | — | - | |
| CHEMBL5598496 | — | IC50 | - | — | - | |
| CHEMBL5597535 | — | IC50 | - | — | - | |
| CHEMBL5598254 | — | IC50 | - | — | - | |
| CHEMBL5597695 | — | IC50 | - | — | - | |
| CHEMBL5597425 | — | IC50 | - | — | - | |
| CHEMBL5591121 | — | IC50 | - | — | - | |
| CHEMBL5597532 | — | IC50 | - | — | - | |
| CHEMBL5596352 | — | IC50 | - | — | - | |
| CHEMBL5596397 | — | IC50 | - | — | - | |
| CHEMBL5598115 | — | IC50 | - | — | - |