Assay Detail
Binding
CHEMBL5589305
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Agonist activity at THR-alpha in HEK293T cells incubated for 18 to 24 hrs by EnSpire plate reader analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.24 | 6.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5596442 | — | — | 1 | 6.76 |
| CHEMBL5597482 | — | — | 1 | 6.72 |
| CHEMBL3261331 | RESMETIROM | 4.0 | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5596442 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL5597482 | — | EC50 | = | 191.0 | nM | 6.72 |
| CHEMBL3261331 | RESMETIROM | EC50 | = | 5930.0 | nM | 5.23 |