Assay Detail
Binding
CHEMBL5608263
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Inhibition of Nano Luc-fused PIM3 (unknown origin) expressed in HEK293 cells using NanoGlo as substrate by NanoBRET In-cell target engagement assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-3 (CHEMBL5407) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.02 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5613918 | — | — | 1 | 7.96 |
| CHEMBL5613782 | — | — | 1 | 7.96 |
| CHEMBL4228654 | — | — | 1 | 7.75 |
| CHEMBL5614352 | — | — | 1 | 7.70 |
| CHEMBL5613647 | — | — | 1 | 7.70 |
| CHEMBL4224859 | — | — | 1 | 7.55 |
| CHEMBL5612624 | — | — | 1 | 7.52 |
| CHEMBL5613324 | — | — | 1 | 7.21 |
| CHEMBL5614031 | — | — | 1 | 7.18 |
| CHEMBL4225287 | — | — | 1 | 6.64 |
| CHEMBL5612131 | — | — | 1 | 6.62 |
| CHEMBL5612824 | — | — | 1 | 6.47 |
| CHEMBL5612698 | — | — | 1 | 6.38 |
| CHEMBL5612145 | — | — | 1 | 6.37 |
| CHEMBL5613954 | — | — | 1 | 5.70 |
| CHEMBL5612629 | — | — | 1 | 5.62 |
| CHEMBL5613392 | — | — | 1 | - |
| CHEMBL5614321 | — | — | 1 | - |
| CHEMBL5613700 | — | — | 1 | - |
| CHEMBL5612961 | — | — | 1 | - |
| CHEMBL5612856 | — | — | 1 | - |
| CHEMBL5613798 | — | — | 1 | - |
| CHEMBL5611959 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5613918 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5613782 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4228654 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5614352 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5613647 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4224859 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5612624 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5613324 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5614031 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4225287 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5612131 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5612824 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5612698 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5612145 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5613954 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5612629 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5613392 | — | IC50 | - | — | - | |
| CHEMBL5614321 | — | IC50 | - | — | - | |
| CHEMBL5613700 | — | IC50 | - | — | - | |
| CHEMBL5612961 | — | IC50 | - | — | - | |
| CHEMBL5612856 | — | IC50 | - | — | - | |
| CHEMBL5613798 | — | IC50 | - | — | - | |
| CHEMBL5611959 | — | IC50 | - | — | - |