Assay Detail
Functional
CHEMBL5608780
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 4-phenyl-5-quinolinyl substituted isoxazole analogues as potent cytotoxic and tubulin polymerization inhibitors against ESCC.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 6.36 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.10 |
| CHEMBL5611956 | — | — | 1 | 7.62 |
| CHEMBL5612773 | — | — | 1 | 7.58 |
| CHEMBL5612523 | — | — | 1 | 7.41 |
| CHEMBL5612387 | — | — | 1 | 7.36 |
| CHEMBL5612680 | — | — | 1 | 7.27 |
| CHEMBL5613572 | — | — | 1 | 7.17 |
| CHEMBL5612733 | — | — | 1 | 7.05 |
| CHEMBL5612595 | — | — | 1 | 6.88 |
| CHEMBL5612345 | — | — | 1 | 6.68 |
| CHEMBL5613083 | — | — | 1 | 6.61 |
| CHEMBL5613687 | — | — | 1 | 6.54 |
| CHEMBL5612685 | — | — | 1 | 6.42 |
| CHEMBL5613679 | — | — | 1 | 6.36 |
| CHEMBL5613218 | — | — | 1 | 6.22 |
| CHEMBL5613480 | — | — | 1 | 6.15 |
| CHEMBL5613290 | — | — | 1 | 6.13 |
| CHEMBL5614183 | — | — | 1 | 6.11 |
| CHEMBL5613886 | — | — | 1 | 6.02 |
| CHEMBL5611938 | — | — | 1 | 6.01 |
| CHEMBL5613492 | — | — | 1 | 5.63 |
| CHEMBL5613317 | — | — | 1 | 5.43 |
| CHEMBL5612730 | — | — | 1 | 5.35 |
| CHEMBL5612065 | — | — | 1 | 5.27 |
| CHEMBL5613487 | — | — | 1 | 5.26 |
| CHEMBL5612459 | — | — | 1 | 5.22 |
| CHEMBL5613974 | — | — | 1 | 5.11 |
| CHEMBL5614151 | — | — | 1 | 5.07 |
| CHEMBL5613676 | — | — | 1 | - |
| CHEMBL5614128 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5611956 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5612773 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5612523 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5612387 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5612680 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5613572 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL5612733 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5612595 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL5612345 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL5613083 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL5613687 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL5612685 | — | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL5613679 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL5613218 | — | IC50 | = | 603.0 | nM | 6.22 |
| CHEMBL5613480 | — | IC50 | = | 705.0 | nM | 6.15 |
| CHEMBL5613290 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5614183 | — | IC50 | = | 773.0 | nM | 6.11 |
| CHEMBL5613886 | — | IC50 | = | 958.0 | nM | 6.02 |
| CHEMBL5611938 | — | IC50 | = | 982.0 | nM | 6.01 |
| CHEMBL5613492 | — | IC50 | = | 2319.0 | nM | 5.63 |
| CHEMBL5613317 | — | IC50 | = | 3678.0 | nM | 5.43 |
| CHEMBL5612730 | — | IC50 | = | 4505.0 | nM | 5.35 |
| CHEMBL5612065 | — | IC50 | = | 5424.0 | nM | 5.27 |
| CHEMBL5613487 | — | IC50 | = | 5534.0 | nM | 5.26 |
| CHEMBL5612459 | — | IC50 | = | 6041.0 | nM | 5.22 |
| CHEMBL5613974 | — | IC50 | = | 7762.0 | nM | 5.11 |
| CHEMBL5614151 | — | IC50 | = | 8576.0 | nM | 5.07 |
| CHEMBL5613358 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5612635 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5612832 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613735 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613631 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5614330 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613045 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5612344 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613895 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5612139 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613465 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613065 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5611922 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5612310 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL5613896 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL5612721 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5611981 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5614074 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL5612980 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL5614128 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL5613676 | — | IC50 | > | 10000.0 | nM | - |