Assay Detail
Functional
CHEMBL5609482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 harboring RT Y188L mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect incubated for 5 days by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-based discovery of novel piperidine-biphenyl-DAPY derivatives as non-nucleoside reverse transcriptase inhibitors featuring improved potency, safety, and selectivity: From piperazine-biphenyl-DAPYs to piperidine-biphenyl-DAPYs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.80 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.80 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.62 |
| CHEMBL5612014 | — | — | 1 | 7.20 |
| CHEMBL5612952 | — | — | 1 | 7.17 |
| CHEMBL5612553 | — | — | 1 | 7.06 |
| CHEMBL5614187 | — | — | 1 | 7.03 |
| CHEMBL5613254 | — | — | 1 | 6.75 |
| CHEMBL5613123 | — | — | 1 | 6.61 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.57 |
| CHEMBL5613811 | — | — | 1 | 6.50 |
| CHEMBL5613183 | — | — | 1 | 6.47 |
| CHEMBL5612529 | — | — | 1 | 6.41 |
| CHEMBL5612205 | — | — | 1 | 6.37 |
| CHEMBL5612631 | — | — | 1 | 6.27 |
| CHEMBL5612186 | — | — | 1 | 6.10 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5612014 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5612952 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5612553 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5614187 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5613254 | — | EC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5613123 | — | EC50 | = | 246.0 | nM | 6.61 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 272.0 | nM | 6.57 |
| CHEMBL5613811 | — | EC50 | = | 313.0 | nM | 6.50 |
| CHEMBL5613183 | — | EC50 | = | 342.0 | nM | 6.47 |
| CHEMBL5612529 | — | EC50 | = | 389.0 | nM | 6.41 |
| CHEMBL5612205 | — | EC50 | = | 431.0 | nM | 6.37 |
| CHEMBL5612631 | — | EC50 | = | 538.0 | nM | 6.27 |
| CHEMBL5612186 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 10000.0 | nM | - |