Assay Detail
Binding
CHEMBL5610442
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Inhibition of hCoV-229E 3CLpro using Dabcyl-KTSAVLQSGFRKM-Glu(Edans) as substrate preincubated 1 hr in presence of 2 mM GSH followed by substrate addition and measured after 30 mins by FRET assay
14
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human coronavirus 229E |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4888440) ↗| Type | SINGLE PROTEIN |
| Organism | Human coronavirus 229E |
Publication
N-acylbenzimidazoles as selective Acylators of the catalytic cystein of the coronavirus 3CL protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.40 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2365410 | — | — | 2 | 7.70 |
| CHEMBL586628 | — | — | 2 | 6.73 |
| CHEMBL5612402 | — | — | 2 | 6.50 |
| CHEMBL5612841 | — | — | 2 | 6.46 |
| CHEMBL5614072 | — | — | 2 | 6.13 |
| CHEMBL5612298 | — | — | 2 | 5.72 |
| CHEMBL5611903 | — | — | 2 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2365410 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2365410 | — | IC50 | = | 22.91 | nM | 7.64 |
| CHEMBL586628 | — | IC50 | = | 186.21 | nM | 6.73 |
| CHEMBL586628 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5612402 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5612402 | — | IC50 | = | 323.59 | nM | 6.49 |
| CHEMBL5612841 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5612841 | — | IC50 | = | 354.81 | nM | 6.45 |
| CHEMBL5614072 | — | IC50 | = | 741.31 | nM | 6.13 |
| CHEMBL5614072 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5612298 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5612298 | — | IC50 | = | 1905.46 | nM | 5.72 |
| CHEMBL5611903 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5611903 | — | IC50 | = | 2630.27 | nM | 5.58 |