Assay Detail
Functional
CHEMBL5610447
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Antiviral activity against HCoV-229E expressing renilla luciferase reporter gene infected in human Huh-7 cells pre-infected with cells for 1 hr followed by compound addition and measured after 6 hrs by luciferase based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human coronavirus 229E |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N-acylbenzimidazoles as selective Acylators of the catalytic cystein of the coronavirus 3CL protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.81 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5614072 | — | — | 1 | 5.32 |
| CHEMBL586628 | — | — | 1 | 5.14 |
| CHEMBL5611903 | — | — | 1 | 4.59 |
| CHEMBL5612402 | — | — | 1 | 4.54 |
| CHEMBL5612841 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5614072 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL586628 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5611903 | — | EC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL5612402 | — | EC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL5612841 | — | EC50 | = | 35600.0 | nM | 4.45 |