Assay Detail
Binding
CHEMBL5611642
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant METTL3/METTL14 extracted from baculovirus infected Hi-5 cells using SAM and 5'-ACGAGUCCUGGACUGAAACGGACUUGU-3' as substrates incubated for 1 hr by MTase-Glo bioluminescence assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Hi-5 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Virtual Screening and Molecular Docking: Discovering Novel METTL3 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.44 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL461101 | ELTROMBOPAG | 4.0 | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL461101 | ELTROMBOPAG | IC50 | = | 3650.0 | nM | 5.44 |