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Assay Detail

CHEMBL5614469

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Functional
Antiproliferative activity against human HCT-116 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Hydroxamic acid hybrids: Histone deacetylase inhibitors with anticancer therapeutic potency.
Pan Y, Hou H, Zhou B, Gao J, Gao F.
Eur J Med Chem (2023) 262 : 115879 -115879
PubMed 37875056 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.03 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5427062 1 6.75
CHEMBL5619510 1 6.74
CHEMBL5435505 1 6.64
CHEMBL5618301 1 6.51
CHEMBL5618517 1 6.51
CHEMBL458997 1 6.14
CHEMBL98 VORINOSTAT 4.0 1 5.99
CHEMBL5619541 1 5.85
CHEMBL5618705 1 5.66
CHEMBL5619313 1 5.66
CHEMBL5218943 1 5.63
CHEMBL5180137 1 5.16
CHEMBL5618265 1 5.15
CHEMBL269538 HARMINE 1.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5427062 IC50 = 180.0 nM 6.75
CHEMBL5619510 IC50 = 182.0 nM 6.74
CHEMBL5435505 IC50 = 230.0 nM 6.64
CHEMBL5618301 IC50 = 310.0 nM 6.51
CHEMBL5618517 IC50 = 310.0 nM 6.51
CHEMBL458997 IC50 = 719.0 nM 6.14
CHEMBL98 VORINOSTAT IC50 = 1030.0 nM 5.99
CHEMBL5619541 IC50 = 1410.0 nM 5.85
CHEMBL5618705 IC50 = 2200.0 nM 5.66
CHEMBL5619313 IC50 = 2200.0 nM 5.66
CHEMBL5218943 IC50 = 2320.0 nM 5.63
CHEMBL5180137 IC50 = 6910.0 nM 5.16
CHEMBL5618265 IC50 = 7010.0 nM 5.15
CHEMBL269538 HARMINE IC50 > 20000.0 nM -