Assay Detail
Binding
CHEMBL5615210
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Inhibition of human recombinant FPPS using IPP as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured after 1 hr
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Farnesyl pyrophosphate synthase inhibitors with antiosteoporosis efficacy in ovariectomized rats: A mixed binding approach beyond bisphosphonates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.40 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL924 | ZOLEDRONIC ACID ANHYDROUS | 4.0 | 1 | 6.26 |
| CHEMBL5619915 | — | — | 1 | 5.96 |
| CHEMBL5618314 | — | — | 1 | 5.91 |
| CHEMBL5618430 | — | — | 1 | 5.61 |
| CHEMBL5618141 | — | — | 1 | 5.49 |
| CHEMBL5619264 | — | — | 1 | 5.47 |
| CHEMBL5618666 | — | — | 1 | 5.26 |
| CHEMBL5619062 | — | — | 1 | 5.22 |
| CHEMBL5619109 | — | — | 1 | 4.90 |
| CHEMBL5619920 | — | — | 1 | 4.67 |
| CHEMBL5619599 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL924 | ZOLEDRONIC ACID ANHYDROUS | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5619915 | — | IC50 | = | 1108.0 | nM | 5.96 |
| CHEMBL5618314 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL5618430 | — | IC50 | = | 2471.0 | nM | 5.61 |
| CHEMBL5618141 | — | IC50 | = | 3216.0 | nM | 5.49 |
| CHEMBL5619264 | — | IC50 | = | 3374.0 | nM | 5.47 |
| CHEMBL5618666 | — | IC50 | = | 5543.0 | nM | 5.26 |
| CHEMBL5619062 | — | IC50 | = | 5980.0 | nM | 5.22 |
| CHEMBL5619109 | — | IC50 | = | 12560.0 | nM | 4.90 |
| CHEMBL5619920 | — | IC50 | = | 21430.0 | nM | 4.67 |
| CHEMBL5619599 | — | IC50 | = | 22660.0 | nM | 4.64 |