Compound Detail
CHEMBL924
ZOLEDRONIC ACID ANHYDROUS 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL924 |
| Name | ZOLEDRONIC ACID ANHYDROUS |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | XRASPMIURGNCCH-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
5
Publications
3
Known Names
8
Indications
Molecular Properties
272.1
MW (Da)
-1.12
ALogP
5
HBA
5
HBD
153.1
PSA (Ų)
0.43
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2001 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Bone Diseases Complex Regional Pain Syndromes Multiple Myeloma Reflex Sympathetic Dystrophy Breast Neoplasms Carcinoma, Renal Cell Kidney Neoplasms Uterine Cervical Neoplasms
Activity Summary
EC50 2 meas. best 8.52
IC50 1 meas. best 6.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 8.52 | 6.625 | 3.0 | 2 |
| Farnesyl pyrophosphate synthase CHEMBL1782 | IC50 | 6.26 | 6.26 | 550.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 3.0 | nM | 8.52 | Induction of Vgamma9Vdelta2 T cells (unknown origin) proliferation assessed as i... | 39026632 |
| Farnesyl pyrophosphate synthase | IC50 | = | 550.0 | nM | 6.26 | Inhibition of human recombinant FPPS using IPP as substrate preincubated with en... | 39018923 |
| Unchecked | EC50 | = | 18500.0 | nM | 4.73 | Induction of Vgamma9Vdelta2 T cell activation in human PBMC cells assessed as CD... | 39026632 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39018923 | 10.1016/j.ejmech.2024.116679 | Rattus norvegicus | 12 |
| 36403421 | 10.1016/j.ejmech.2022.114935 | Phosphoserine phosphatase SerB2 | 3 |
| 39026632 | 10.1039/d4md00208c | Unchecked | 2 |
| 36446206 | 10.1016/j.ejmech.2022.114948 | BMDM | 1 |
| 39018923 | 10.1016/j.ejmech.2024.116679 | Farnesyl pyrophosphate synthase | 1 |
Data from ChEMBL 36 via Core Engine