Assay Detail
Functional
CHEMBL5586166
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Induction of Vgamma9Vdelta2 T cells (unknown origin) proliferation assessed as increase in IPP accumulation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Not specified |
| Cell Type | Vgamma9Vdelta2 T cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Phosphonodiamidate prodrugs of phosphoantigens (ProPAgens) exhibit potent Vγ9/Vδ2 T cell activation and eradication of cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.96 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145233 | — | — | 1 | 10.22 |
| CHEMBL924 | ZOLEDRONIC ACID ANHYDROUS | 4.0 | 1 | 8.52 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 7.10 |
| CHEMBL356362 | ISOPENTENYLPYROPHOSPHATE | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145233 | — | EC50 | = | 0.06 | nM | 10.22 |
| CHEMBL924 | ZOLEDRONIC ACID ANHYDROUS | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL923 | RISEDRONIC ACID | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL356362 | ISOPENTENYLPYROPHOSPHATE | EC50 | = | 1000.0 | nM | 6.00 |