Assay Detail
Functional
CHEMBL5615463
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of RSL3-based GPX4 degraders with hydrophobic tags.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.09 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5619123 | — | — | 1 | 7.62 |
| CHEMBL5618124 | — | — | 1 | 7.55 |
| CHEMBL5620148 | — | — | 1 | 7.52 |
| CHEMBL5619483 | — | — | 1 | 7.44 |
| CHEMBL5619995 | — | — | 1 | 7.39 |
| CHEMBL5618627 | — | — | 1 | 7.24 |
| CHEMBL5618742 | — | — | 1 | 7.19 |
| CHEMBL5619027 | — | — | 1 | 7.19 |
| CHEMBL5619810 | — | — | 1 | 7.15 |
| CHEMBL4747331 | — | — | 1 | 7.05 |
| CHEMBL5618514 | — | — | 1 | 6.92 |
| CHEMBL5619838 | — | — | 1 | 6.91 |
| CHEMBL5618164 | — | — | 1 | 6.79 |
| CHEMBL5619716 | — | — | 1 | 6.70 |
| CHEMBL5619773 | — | — | 1 | 6.42 |
| CHEMBL5618371 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5619123 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5618124 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5620148 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5619483 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5619995 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5618627 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5618742 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5619027 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5619810 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4747331 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5618514 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5619838 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL5618164 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL5619716 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5619773 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5618371 | — | IC50 | = | 498.0 | nM | 6.30 |