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Assay Detail

CHEMBL5615903

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity against mouse NIH3T3 cells incubated for 5 days by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Mus musculus
Cell Type NIH3T3
Confidence 1 — Organism
Curated By Autocuration

Target

NIH3T3 (CHEMBL614822)
Type CELL-LINE
Organism Mus musculus

Publication

Emerging therapeutics: The imidazo[1,2-b]pyridazine scaffold as a novel drug candidate for eumycetoma, a neglected tropical disease.
Elkheir LYM, Delaye PO, Penichon M, Eadie K, Mohamed MA, Besson P, Chesnay A, Desoubeaux G, Roger S, van de Sande WWJ, Fahal AH, Enguehard-Gueiffier C.
Eur J Med Chem (2024) 277 : 116720 -116720
PubMed 39142148 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.00 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5618545 1 5.85
CHEMBL5618845 1 5.05
CHEMBL5618754 1 5.05
CHEMBL5619519 1 5.02
CHEMBL5620278 1 5.00
CHEMBL5619827 1 5.00
CHEMBL5620178 1 4.99
CHEMBL5619093 1 4.98
CHEMBL5618839 1 4.98
CHEMBL5619642 1 4.97
CHEMBL5619326 1 4.92
CHEMBL5619138 1 4.91
CHEMBL5618921 1 4.89
CHEMBL5620050 1 4.88
CHEMBL64391 ITRACONAZOLE 4.0 1 4.86
CHEMBL5618392 1 4.84
CHEMBL5618267 1 4.84

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5618545 IC50 = 1400.0 nM 5.85
CHEMBL5618845 IC50 = 9000.0 nM 5.05
CHEMBL5618754 IC50 = 9000.0 nM 5.05
CHEMBL5619519 IC50 = 9600.0 nM 5.02
CHEMBL5620278 IC50 = 10100.0 nM 5.00
CHEMBL5619827 IC50 = 9900.0 nM 5.00
CHEMBL5620178 IC50 = 10200.0 nM 4.99
CHEMBL5619093 IC50 = 10500.0 nM 4.98
CHEMBL5618839 IC50 = 10500.0 nM 4.98
CHEMBL5619642 IC50 = 10700.0 nM 4.97
CHEMBL5619326 IC50 = 11900.0 nM 4.92
CHEMBL5619138 IC50 = 12300.0 nM 4.91
CHEMBL5618921 IC50 = 12900.0 nM 4.89
CHEMBL5620050 IC50 = 13100.0 nM 4.88
CHEMBL64391 ITRACONAZOLE IC50 = 13700.0 nM 4.86
CHEMBL5618392 IC50 = 14600.0 nM 4.84
CHEMBL5618267 IC50 = 14300.0 nM 4.84