Assay Detail
Binding
CHEMBL5616321
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Inhibition of PTPN2 (unknown origin)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 2 (CHEMBL3807) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Regulation of protein phosphorylation by PTPN2 and its small-molecule inhibitors/degraders as a potential disease treatment strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.12 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5619806 | — | — | 1 | 9.24 |
| CHEMBL5095164 | OSUNPROTAFIB | 2.0 | 1 | 8.74 |
| CHEMBL5618445 | — | — | 1 | 8.70 |
| CHEMBL5619195 | — | — | 1 | 8.41 |
| CHEMBL259628 | — | — | 1 | 8.15 |
| CHEMBL5618838 | — | — | 1 | 8.00 |
| CHEMBL5618189 | — | — | 1 | 8.00 |
| CHEMBL5618163 | — | — | 1 | 7.89 |
| CHEMBL5619999 | — | — | 1 | 7.57 |
| CHEMBL5619752 | — | — | 1 | 7.38 |
| CHEMBL590122 | — | — | 1 | 7.19 |
| CHEMBL5618850 | — | — | 1 | - |
| CHEMBL5619034 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5619806 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL5095164 | OSUNPROTAFIB | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5618445 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5619195 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL259628 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL5618838 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5618189 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5618163 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5619999 | — | IC50 | = | 27.1 | nM | 7.57 |
| CHEMBL5619752 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL590122 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5618850 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL5619034 | — | IC50 | < | 5.0 | nM | - |