Assay Detail
Binding
CHEMBL5617583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TDO transfected in HEK293T cells using L-tryptophan as substrate incubated for 24 hrs by absorbance based microplate analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, synthesis and biological evaluation of novel isoquinoline derivatives as potent indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.94 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1812545 | — | — | 1 | 5.91 |
| CHEMBL5618748 | — | — | 1 | 5.14 |
| CHEMBL5620309 | — | — | 1 | 4.83 |
| CHEMBL5619421 | — | — | 1 | 4.83 |
| CHEMBL5618425 | — | — | 1 | 4.65 |
| CHEMBL5618823 | — | — | 1 | 4.62 |
| CHEMBL5618165 | — | — | 1 | 4.59 |
| CHEMBL5618428 | — | — | 1 | - |
| CHEMBL5619903 | — | — | 1 | - |
| CHEMBL5619886 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1812545 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL5618748 | — | IC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL5620309 | — | IC50 | = | 14610.0 | nM | 4.83 |
| CHEMBL5619421 | — | IC50 | = | 14770.0 | nM | 4.83 |
| CHEMBL5618425 | — | IC50 | = | 22330.0 | nM | 4.65 |
| CHEMBL5618823 | — | IC50 | = | 23950.0 | nM | 4.62 |
| CHEMBL5618165 | — | IC50 | = | 25850.0 | nM | 4.59 |
| CHEMBL5618428 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5619903 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5619886 | — | IC50 | > | 30000.0 | nM | - |