Assay Detail
Binding
CHEMBL5620517
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) expressed in Bac-to-Bac baculovirus expression system measured after 2 hrs by ELISA method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent advances of novel fourth generation EGFR inhibitors in overcoming C797S mutation of lung cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.22 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5624606 | — | — | 1 | 9.55 |
| CHEMBL5190294 | — | — | 1 | 8.51 |
| CHEMBL4294743 | — | — | 1 | 8.24 |
| CHEMBL4214567 | — | — | 1 | 7.89 |
| CHEMBL4098072 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5624606 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL5190294 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4294743 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4214567 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4098072 | — | IC50 | = | 130.0 | nM | 6.89 |