Assay Detail
Binding
CHEMBL5620542
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE3 expressed in Escherichia coli
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Advances in the development of phosphodiesterase 7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.71 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5625125 | — | — | 1 | 9.12 |
| CHEMBL4297384 | GSK-356278 | 1.0 | 1 | 8.30 |
| CHEMBL5631032 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5625125 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL4297384 | GSK-356278 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5631032 | — | IC50 | > | 10000.0 | nM | - |