Compound Detail
CHEMBL5631032
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Basic Information
| ChEMBL ID | CHEMBL5631032 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MWCXBSHDZTZKGN-SVXKRPBISA-N |
| Parent Compound | CHEMBL6069026 |
| Active Moiety | CHEMBL6069026 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
365.5
MW (Da)
4.32
ALogP
5
HBA
0
HBD
39.4
PSA (Ų)
0.68
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 7 CHEMBL2111411 | IC50 | 5.8 | 5.8 | 1590.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 7 | IC50 | = | 1590.0 | nM | 5.8 | Inhibition of full length PDE7 (unknown origin) using FAM-cAMP as substrate by f... | 36796299 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36796299 | 10.1016/j.ejmech.2023.115194 | Phosphodiesterase 7 | 1 |
| 36796299 | 10.1016/j.ejmech.2023.115194 | Phosphodiesterase 3 | 1 |
Data from ChEMBL 36 via Core Engine